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Schisandra Chinensis Protects against Adriamycin-Induced Cardiotoxicity in Rats

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Author(s): Jyh-Sheng You | Tai-Long Pan | Yu-Chang Hou

Journal: Chang Gung Medical Journal
ISSN 2072-0939

Volume: 29;
Issue: 01;
Start page: 63;
Date: 2006;
Original page

Keywords: http://memo.cgu.edu.tw/cgmj/2901/290106.pdf

ABSTRACT
Background: Adriamycin (ADR) is an effective chemotherapeutic agent against cancersbut its clinical use is limited due to its cardiotoxicity. It has been suggestedthat the pathogenesis involves inhibition of nucleic acid and protein synthesis,free radical formation and lipid peroxidation. Schisandra chinensis (SC)has strong antioxidant activity. We investigate the protective effects of SC onadriamycin-induced cardiotoxicity.Methods: Wistar rats were divided into four groups: CONT (control), ADR, SC and SC+ ADR. After treatment, the hearts of the rats were surgically removed andstudied for synthesis rates of nucleic acid and protein, myocardial antioxidantsand lipid peroxidation.Results: Cardiotoxicity was characterized by ascites, congested liver and depressedcardiac function. Nucleic acid and protein synthesis were inhibited, malondialdehyde(MDA) was increased, while myocardial glutathione peroxidase(GSHPx) activity and superoxide dismutase (SOD) were decreased by ADR.In contrast, administration of SC before and concurrent with ADR significantlyreduced mortality and the amount of ascites. Indexes in myocardialGSHPx, macromolecular biosynthesis and SOD activities increased with aconcomitant decrease in lipid peroxidation.Conclusion: These results suggest that ADR cardiotoxicity is associated with antioxidantdeficit and SC treatment changes the antioxidant status of the heart andimproves cardiac function.

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Tangokurs Rapperswil-Jona

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