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SCREENING OF ETHANOLIC EXTRACT OF STACHYTARPHETA INDICA L. (VAHL) LEAVES FOR HEPATOPROTECTIVE ACTIVITY

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Author(s): Joshi VG | Sutar P S | Karigar A A | Patil S A | Gopalakrishna B | Sureban R R

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 1;
Issue: 1;
Start page: 174;
Date: 2010;
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Keywords: Stachytarpheta indica L. (Vahl) | Ethanolic extract | Carbon tetrachloride | Hepatoprotective activity.

ABSTRACT
Petroleum ether, Chloroform, Ethanol and Aqueous extract of shade dried leaves of Stachytarpheta indica L. (Vahl) were subjected for phytochemical studies. Ethanolic extract showed the presence of Carbohydrates, Glycosides and Flavanoids. Most of the active constituents were present in Ethanolic extract and hence extract was further evaluated for hepatoprotective activity. Hepatoprotective activity of Ethanolic extract of Stachytarpheta indica L. (Vahl) was evaluated by carbon tetrachloride induced toxicity with standard hepatoprotective drug as Liv-52. Ethanolic extract of Stachytarpheta indica L. (Vahl) produced reduction in CCl4 induced elevated levels of SGPT, SGOT, SALP and Serum bilirubin and reversed total protein in rats indicating hepatoprotective activity at the dose of 200mg/kg body weight and was comparable to that of standard drug Liv-52(1ml/kg body weight).Further histopathological studies indicated that the animals pretreated with ethanolic extract of Stachytarpheta indica L. (Vahl) was minimal with distinct preservation of structures and architectural frame of the hepatic cells, and is comparable to standard Liv-52.
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