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Sedative and Anticonvulsant Properties of the Decoction of Balanites aegyptiaca (Balanitaceae)

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Author(s): Elisabeth Ngo Bum | Neteydji Sidiki | Taiwe | Paul Fasutin Seke Etet | Frededic Maidawa | Silvere Vincent Rakotonirina | Alice Rakotonirina

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 4;
Issue: 1;
Start page: 34;
Date: 2005;
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ABSTRACT
The decoction of Balanites aegyptiaca, a plant used in traditional medicine in Africa for many diseases, possesses anticonvulsant and sedative activity in mice. This decoction protected mice against strychnine- and pentylenetetrazol-induced seizures. But Balanites aegyptiaca decoction had no effect against picrotoxin-induced seizures. In the other side, the decoction of Balanites aegyptiaca potentiated sleep-induced by diazepam. The total sleep time of the control group was multiply by 4 in the presence of the decoction at a dose of 1000 mg /kg (from 12 to 59 min). With these effects, the decoction of Balanites aegyptiaca L. seem to posses sedative and anticonvulsant properties that might explain its use as a traditional medicine for epilepsy in Africa.
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