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Selectina-E, VCAM-1, FNT-α, IL-6, PCR y Fibrinógeno plasmático como marcadores de inflamación en la aterosclerosis, en conejos machos Nueva Zelanda, expuestos a una dieta hiperlipidémica

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Author(s): Julio C González | Leticia Figueira | Aldo Reigosa

Journal: Salus Online
ISSN 1316-7138

Volume: 12;
Issue: 2;
Start page: 81;
Date: 2008;
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Keywords: E-selectin | VCAM-1 | TNF-α | IL-6 | CRP | Fibrinogen | hyperlipidaemia | atheroma | inflammation.

ABSTRACT
Inflammation markers have been involved in the development and progression of atherosclerosis. The objective of the present study was to compare plasma concentration of E-selectin, VCAM-1, TNF-α, IL-6, CRP and Fibrinogen as inflammation markers for atherosclerosis in two groups of rabbits. 19 male New Zealand rabbits were divided into two groups: Group1: Was fed “conejarina” (commercial rabbit food) and vegetable; Group2: Eggs and “conejarina”. The experimental period lasted 11 weeks. Serum cholesterol and triglycerides determination was done by enzymatic methods, HDL-c and LDL-c by extraction and enzymatic determination, E-selectin, VCAM-1, TNF-α and IL-6 by ELISA, CRP and Fibrinogen by nefelometry prior the experiment, and in weeks 4, 8 and 11. The rabbits were sacrificed and a histological study of their aorta was done. Results revealed that in group 2, E-selectin, VCAM-1, TNF-α and CRP increased from week 4 (p
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