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Self-Assembled Dextrin Nanogel as Curcumin Delivery System

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Author(s): Catarina Gonçalves | Paula Pereira | Peter Schellenberg | Paulo J. Coutinho | Francisco M. Gama

Journal: Journal of Biomaterials and Nanobiotechnology
ISSN 2158-7027

Volume: 03;
Issue: 02;
Start page: 178;
Date: 2012;
Original page

Keywords: Curcumin | Dextrin | Nanogel | Drug Delivery | Cytotoxicity

ABSTRACT
Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this study, we show that self-assembled nanogels obtained from hydrophobically modified dextrin are effective curcumin nanocarriers. The stability and loading efficiency of curcumin-loaded nanogel depends on the nanogel/curcumin ratio. Higher stability of the formulation is achieved in water than in PBS buffer, as evaluated by dynamic light scattering and fluorescence measurements. The in vitro release profile, using sink conditions, indicates that dextrin nanogel may perform as a suitable carrier for the controlled release of curcumin. Biological activity of curcumin-loaded nanogel in HeLa cell cultures was assessed using the MTS assay.
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