Academic Journals Database
Disseminating quality controlled scientific knowledge

Self Emulsifying Drug Delivery System : A Review

Author(s): Padma priya S*, Patel Krunal kumar, Kausalya J, , Ravichandiran V

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3483;
Date: 2011;
Original page

Keywords: Self emulsifying drug delivery | oil | co-solvents | surfactant | self-micro-emulsifying drug delivery systems (SMEDDS). Hydrophobic drugs

The oral delivery of hydrophobic drugs presents a major challenge because of the low aqueous solubility of such compounds. Self emulsifying drug delivery systems(SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co solvents/surfactants can be used for the design of formulations in order to improve theoral absorption of highly lipophilic drug compounds. SEDDS can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil-in-water(o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids. The efficiency of oral absorption of the drug compound from theSEDDS depends on many formulation-related parameters, such as surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge,all of which in essence determine the self-emulsification ability. Thus, only very specific pharmaceutical excipient combinations will lead to efficient selfemulsifyingsystems. The fact that almost 40% of the new drug compounds are hydrophobic in nature implies that studies with SEDDS will continue, and more drugcompounds formulated as SEDDS will reach the pharmaceutical market in the future. This review will highlight the overall view of the Self emulsifying drug deliverysystems.
Affiliate Program     

Tango Jona
Tangokurs Rapperswil-Jona