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Sepsis-induced acute kidney injury

Author(s): Majumdar Arghya

Journal: Indian Journal of Critical Care Medicine
ISSN 0972-5229

Volume: 14;
Issue: 1;
Start page: 14;
Date: 2010;
Original page

Keywords: Sepsis | acute kidney injury | AKI | acute renal failure | extracorporeal purification of blood

Acute kidney injury (AKI) is a common sequel of sepsis in the intensive care unit. It is being suggested that sepsis-induced AKI may have a distinct pathophysiology and identity. Availability of biomarkers now enable us to detect AKI as early as four hours after it′s inception and may even help us to delineate sepsis-induced AKI. Protective strategies such as preferential use of vasopressin or prevention of intra-abdominal hypertension may help, in addition to the other global management strategies of sepsis. Pharmacologic interventions have had limited success, may be due to their delayed usage. Newer developments in extracorporeal blood purification techniques may proffer effects beyond simple replacement of renal function, such as metabolic functions of the kidney or modulation of the sepsis cascade.

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