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Serial testing with an interferon-γ release assay in German healthcare workers

Author(s): Schablon, Anja | Harling, Melanie | Diel, Roland | Ringshausen, Felix C. | Torres Costa, Jose | Nienhaus, Albert

Journal: GMS Krankenhaushygiene Interdisziplinär
ISSN 1863-5245

Volume: 5;
Issue: 2;
Start page: Doc05;
Date: 2010;
Original page

Keywords: serial testing | interferon-gamma release assay | latent TB infection | healthcare workers

Aim: Data concerning conversion and reversion rates in the serial testing of healthcare workers (HCWs) is rare. So far, there is no consensus on how to define and interpret interferon-gamma release assays (IGRA) conversions and reversions, or how to deal with such results. We analysed conversion and reversion rates in the serial testing of HCWs using an IGRA. Methods: The study population comprises 287 HCWs, who participated in routine occupational safety and health screening for latent tuberculosis infection (LTBI) with the QuantiFERON-TB® Gold In-Tube assay (QFT). Four different definitions for conversion and reversion were applied: 1) transgression or regression above/below the cut-off; 2) increase from 0.7 IU/ml or decrease from >0.7 to
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