Academic Journals Database
Disseminating quality controlled scientific knowledge

Seroprevalence and distribution of arboviral infections among rural Kenyan adults: A cross-sectional study

Author(s): Mease Luke | Coldren Rodney | Musila Lillian | Prosser Trish | Ogolla Fredrick | Ofula Victor | Schoepp Randal | Rossi Cindy | Adungo Nicholas

Journal: Virology Journal
ISSN 1743-422X

Volume: 8;
Issue: 1;
Start page: 371;
Date: 2011;
Original page

Keywords: arbovirus | Kenya | flavivirus | dengue virus | West Nile virus | yellow fever virus | chikungunya virus | Rift Valley fever virus

Abstract Background Arthorpod-borne viruses (arboviruses) cause wide-spread morbidity in sub-Saharan Africa, but little research has documented the burden and distribution of these pathogens. Methods Using a population-based, cross-sectional study design, we administered a detailed questionnaire and used ELISA to test the blood of 1,141 healthy Kenyan adults from three districts for the presence of anti-viral Immunoglobulin G (IgG) antibodies to the following viruses: dengue (DENV), West Nile (WNV), yellow fever (YFV), Chikungunya (CHIKV), and Rift Valley fever (RVFV). Results Of these, 14.4% were positive for DENV, 9.5% were WNV positive, 9.2% were YFV positive, 34.0% were positive for CHIKV and 0.7% were RVFV positive. In total, 46.6% had antibodies to at least one of these arboviruses. Conclusions For all arboviruses, district of residence was strongly associated with seropositivity. Seroprevalence to YFV, DENV and WNV increased with age, while there was no correlation between age and seropositivity for CHIKV, suggesting that much of the seropositivity to CHIKV is due to sporadic epidemics. Paradoxically, literacy was associated with increased seropositivity of CHIKV and DENV.
Affiliate Program      Why do you need a reservation system?