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Serum adiponectin and IL-6 levels in diabetic foot ulcer subjects

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Author(s): D.Rekha Kumari | M.Farid Babu | K.Balu Mahendran | P.Satyanarayana | K.R.S.Sambasiva

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 04;
Issue: 02;
Start page: 69;
Date: 2013;
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Keywords: Adiponectin | Diabetes | Diabetic foot ulcer (DFU) and IL-6

ABSTRACT
Aim: To evaluate adiponectin, IL6 and various biochemical parameters in the diabetic foot ulcer subjects.Methods: A total of 30 diabetic foot ulcer patients, 30 diabetic patients and 30 healthy individuals (control) are selected for this study. Adiponectin and IL6 levels are analysed by ELISA kit. Results: The mean level of adiponectin is significantly decreased in diabetic foot ulcer patients than compare to diabetic and healthy individuals (12.1±1.32 vs 7.35±1.78 vs 5.7±1.10µg/mL.The mean level of IL6 levels are significantly increased due to inflammation (2.5±1.1 vs 2.6±0.2 vs 4.3±0.9pg/mL).Conclusions: Serum adiponectin levels are significantly decreased and simultaneously IL-6 levels are increased patients with diabetic foot ulcer. Our study demonstrated that low adiponectin level is one of the markers for the poor maintenance of blood glucose level and IL-6 is a potent inflammatory marker in diabetic foot ulcer patients.
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