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Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients

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Author(s): Tsutomu Nakamura, Takeshi Ioroi, Toshiyuki Sakaeda, Masanori Horinouchi, Nobuhide Hayashi, Kensuke Saito, Mitsuro Kosaka, Noboru Okamura, Keiichi Kadoyama, Shunichi Kumagai, Katsuhiko Okumura

Journal: International Journal of Medical Sciences
ISSN 1449-1907

Volume: 3;
Issue: 3;
Start page: 92;
Date: 2006;
Original page

ABSTRACT
Cystatin C (Cys-C) has been recently paid great attention as a better endogenous marker of the glomerular filtration rate than creatinine (Cr). In this study, the usefulness of Cys-C was compared with Cr in terms of the estimation of the steady-state serum trough concentrations of digoxin in Japanese patients. Forty patients treated with digoxin and 56 healthy elderly subjects were participated in this study. The serum levels of Cys-C and Cr in the patients were higher than those in the healthy elderly subjects, but the increase of Cys-C was more predominant in the patients. Their levels were well-correlated for both of the healthy elderly subjects (r=0.691) and patients (r=0.774), but the serum concentrations of digoxin were better correlated with those of the reciprocal values of Cr (r=0.667) than those of Cys-C (r=0.383), presumably due to the fact that digoxin and Cr were excreted via both glomerular filtration and tubular secretion. Cys-C is useful for the substratification of the patients diagnosed to have normal renal function with Cr of < 1.3 mg/dL into those with normal and pseudo-normal renal function, resulting in the corresponding serum concentrations of digoxin.
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