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Serum Metabonomic Study of 2 Uyghur Probable MODY Families Based on 1H NMR

Author(s): Dr. Patamu Mohemaiti | Ylilihamujiang Yimamu

Journal: Journal of Diabetes & Metabolism
ISSN 2155-6156

Volume: 2;
Issue: 22;
Date: 2011;
Original page

Keywords: Probable MODY family | Metabonormic study | 1H NMR

Objective: To study the characteristics of changes in serum metabolites in two Uyghur families with probable maturity-onset diabetes of young (MODY). Method: We gathered two probable MODY families composed of four generations of Uyghurs from Kashgar region, Xinjiang Uyghur Autonomous Region, China. A total of 52 family members were gathered. Their general information, measured blood glucose levels, blood lipid levels, and blood pressure were analyzed. Using 1H Nuclear Magnetic Resonance (1H NMR) spectroscopy, serum metabolites were measured for each study participants. After having conducted data pretreatment on the spectrogram, orthogonal partial least squares discriminant analysis (OPLS-DA) was used to interpret data. We divided subjects into two groups according to blood glucose (norrmal and high), blood pressure, body mass index (BMI) levels, and compared the metabolites. We determined differences of metabolism components between each group’s serum using pearson correlation coefficients with significant difference detection and two-dimensional spectrum technology. Results: ➀Isoleucine and tyrosine levels were decreased significantly (p
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