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Serum oxidative stress status in CagA positive Helicobacter pylori infection

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Author(s): Zeliha Asiltürk | Yaşar Nazlıgül | Mehmet Yıldız | Metin Küçükazman | Oktay Bulur | Ayla Tezer | Zeynep Çizmeci | Kadir Okhan Akın

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 2;
Start page: 202;
Date: 2011;
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Keywords: Helicobacter pylori | CagA | oxidative status | total antioxidant status | total oxidant status | oxidative stress index

ABSTRACT
Previous studies have suggested that CagA positive Helicobacter pylori (H.pylori) infection may cause the various oxidative damages. The objective of this study was to investigate serum oxidative status in infectetion with CagA positive H.pylori strains.Materials and methods: Forty-two H.pylori CagA positive subjects and 39 H.pylori CagA negative subjects were enrolled. H.pylori infection was diagnosed by the histopathological assessment of gastric mucosa. CagA status was detected by enzyme immuno assay in a micro ELISA machine. Total antioxidant status (TAS) and total oxidant status (TOS) were measured autoanalyzer using commercially available kits. Serum oxidative stress index (OSI) was calculated using TAS and TOS measurements.Results: The levels TAS and TOS of CagA positive subjects were found to be 1.48 ± 0.18 mmol/L, 36.88 ± 19.84 mmol/L. Those of CagA negative group were measured to be 1.43 ± 0.19 mmol/L and 38.44 ± 14.72 mmol/L respectively. The values of serum OSI were similar (25.28 ± 15.85 and 26.48 ± 10.02) in CagA positive and negative groups.Conclusions: The measurements of serum oxidative status did not show any sigficant difference between the patients infected with CagA positive and CagA negative H.pilori strains. J Clin Exp Invest 2011;2(2):202-6
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