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Serum Survivin and TP53 Gene Expression in Children with Acute Lym-phoblastic Leukemia

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Author(s): Raida S Yahya | Manal I Fouda | Hatim A El-Baz | Tamer E Mosa | Mohamed D Abd ElMaksoud

Journal: Iranian Journal of Public Health
ISSN 2251-6085

Volume: 41;
Issue: 1;
Start page: 37;
Date: 2012;
Original page

Keywords: Survivin | P53 | Acute Lymphoblastic Leukemia | Gene Expression | ELISA | Flow Cytometry

ABSTRACT
Background: The aim of this study was to detect the prognostic significance of survivin level and the expression of total p53 in acute lymphoblastic leukemia (ALL) and its correlation to patients' outcome.Methods: Sixty two children newly diagnosed with acute lymphoblastic leukemia were treated with chemotherapy and followed up for 2 years or until death. Twenty apparently healthy volunteers with matched age and sex were taken as control. Survivin protein was measured by quantitative sandwich enzyme immunoassay and total human p53 was measured by Flow cytometry in peripheral blood at diagnosis and at complete remission.Results: A highly significant elevation (P
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