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Serum and tissue levels of interleukin-12 and interleukin-18 in intestinal type gastric cancer

Author(s): Dorota Diakowska, Krzysztof Grabowski, Mirosław Nienartowicz, Piotr Szelachowski, Krystyna Markocka-Mączka

Journal: Polish Gastroenterology
ISSN 1232-9886

Volume: 18;
Issue: 3;
Start page: 103;
Date: 2011;
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Keywords: gastric cancer | interleukin-12 | interleukin-18

Introduction: Interleukin-12 (IL-12) and interleukin-18 (IL-18) have implication in tumor's immunology. Aim of the study was to evaluate the concentrations of IL-12 and IL-18 in serum and tumor tissues of patients with intestinal type gastric cancer (GC). The relationship between the levels of these cytokines and clinicopathological parameters was investigated. Material and methods: IL-12 and IL-18 concentrations were measured by ELISA tests in serum from 57 patients with GC and 38 healthy subjects, and in tissue homogenates - from 29 operated GC patients. Results: Serum levels of IL-12 and IL-18 were significantly higher in GC patients than in control (p
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