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Serum Zinc Levels in Children and Adolescents With Type-1 Diabetes Mellitus

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Author(s): M Estakhri | A Djazayery | MR Eshraghian | R Majdzadeh | M Jalali | Z Karamizadeh | M Chamari | M Peyrovi Milani

Journal: Iranian Journal of Public Health
ISSN 2251-6085

Volume: 40;
Issue: 4;
Start page: 83;
Date: 2011;
Original page

Keywords: Zinc | Type-1 Diabetes Mellitus | Children | Adolescents | Hemoglobin A1c

ABSTRACT
Background: There have been very few studies, with contradictory results, on the zinc status of children and adolescents with type-1 diabetes mellitus. The objective of this cross-sectional study was to determine zinc status based on the serum zinc concentration in type-1 diabetic children and adolescents and compare it with that of healthy controls.Methods: Thirty children and adolescents with type-1 diabetes mellitus, aged 6 to 18 years, and 30 age- and sex-matched healthy controls participated in the study. Serum zinc, fasting blood sugar, hemoglobin A1c and serum albumin were meas­ured by flame atomic absorption spectrophotometry, enzymatic colorimetry, ion-exchange chromatography and colorimetry using bromocresol green methods, respectively.Results: No statistically significant difference was found in the mean serum zinc concentration between diabetic patients and healthy controls (111.0 ± 3.1 and 107.1 ± 3.8 mg/dl respectively, P= 0.4). No correlations were found between the serum zinc levels and fasting blood sugar, hemoglobin A1c, or the duration of the disease in the patients.Conclusion: The zinc levels of diabetic children and adolescents are not noticeably different compared to those of healthy controls and are independent of glycemic control and the duration of the disease.
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