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Severe myocardial depression in a patient with aluminium phosphide poisoning: A clinical, electrocardiographical and histopathological correlation

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Author(s): Shah Viral | Baxi Seema | Vyas Tanmay

Journal: Indian Journal of Critical Care Medicine
ISSN 0972-5229

Volume: 13;
Issue: 1;
Start page: 41;
Date: 2009;
Original page

Keywords: Aluminium phosphide | myocardial depression | myocyte vacuolation | myocytolysis | phosphide poisoning

ABSTRACT
Aluminium phosphide poisoning is very common in India. It is one of the most fatal poisons. The clinical spectrum of poisoning varies depending upon the dosage and duration of consumption. The main effect of the poison is due to the release of phosphine which inhibits cytochrome oxidase and thereby hampers cellular oxygen utilization. Almost any organ can be affected by aluminium phosphide poisoning. We report a case where the heart was the predominantly affected organ. We describe the clinical symptoms and signs and their correlation with electrocardiographic and histopathological examinations.

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