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A Short Synthesis of Bisabolane Sesquiterpenes

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Author(s): Zhen-Ting Du | Shuai Zheng | Gang Chen | Dong Lv

Journal: Molecules
ISSN 1420-3049

Volume: 16;
Issue: 9;
Start page: 8053;
Date: 2011;
Original page

Keywords: curcumene | xanthorrhizol | curcuhydroquinone | synthesis

ABSTRACT
A facile total synthesis of three members of the bisabolane sesquiterpene family, namely (±)-curcumene, (±)-xanthorrhizol and (±)-curcuhydroquinone had been achieved in high overall yield. The synthesis used bromobenzene derivatives as starting materials. The halogen-lithium exchange followed by addition of isoprenylacetone and reduction of the obtained carbinols are the key steps of the synthetic pathway. This synthetic approach provides a new route to the bisabolane sesquiterpenes.
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