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Sideróforos: uma resposta dos microorganismos

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Author(s): Benite Anna Maria Canavarro | Machado Sérgio de Paula | Machado Bianca da Cunha

Journal: Química Nova
ISSN 0100-4042

Volume: 25;
Issue: 6b;
Start page: 1155;
Date: 2002;
Original page

Keywords: iron | coordination compounds | natural chelators

ABSTRACT
Siderophores (from the Greek: "iron carriers") are defined as relatively low molecular weight, ferric ion specific chelating agents elaborated by microorganisms growing under low iron stress. The role of these compounds is to scavenge iron from the environment and to make this essential chemical element available to the microbial cell. The present paper is a brief presentation of siderophore coordination chemistry with emphasis on those aspects relevant to the transportation of iron (III) complexes across biological membranes. Finally, the role of siderophores in infection and their clinical potential as iron scavenging molecules are reviewed.
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Tango Rapperswil
Tango Rapperswil