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Signal Intensity Reduction May Be Prior to Height or Volume Loss in Pituitary Gland MRI of Beta-Thalassemic Patients with Hypogonadotropic Hypogonadism

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Author(s): Ali Hekmatnia | Amir Reza Radmard | Ali Asghar Rahmani | Ali Hekmatnia | Manijeh Motaghi | Farideh Naghshineh

Journal: Iranian Journal of Radiology
ISSN 1735-1065

Volume: 6;
Issue: S1;
Start page: 80;
Date: 2009;
Original page

ABSTRACT
"nIntroduction: Pituitary iron overload in patients with transfusion-dependent beta-thalassemia may lead to delayed puberty. MRI has the potential to estimate excessive iron accumulation in the pituitary gland by measuring its dimensions or signal intensity. This study investigates the association of pituitary MRI findings and the pubertal status in thalassemic patients as well as demonstrating any priority to reveal these manifestations. "nMaterials and Methods: Twenty seven beta-thalassemic patients, aged 15-24 years, including 13 patients with delayed puberty (Group A) and 14 normal puberty (Group B) were enrolled. They were matched by age, gender, duration of transfusion and chelation therapy. Thirty eight age and sex adjusted healthy subjects were also included as the control group (Group C). All participants underwent pituitary MRI using a 1.5T unit. Pituitary-to-fat signal intensity ratios (SIR) were calculated from coronal T2-weighted images. Estimated pituitary volumes were measured using pituitary height, width and length. Data were expressed as meanĀ± SD and analyzed using Student's t test. "nResults: The pituitary-to-fat SIRs were significantly lower in group A compared with group B (P

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