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Significance of different animal species in experimental models for in vivo investigations of hematopoiesis

Author(s): Kovačević-Filipović Milica | Božić Tatjana P. | Stevanović Jelka Ž.

Journal: Veterinarski Glasnik
ISSN 0350-2457

Volume: 58;
Issue: 1-2;
Start page: 55;
Date: 2004;
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Keywords: animals | experimental models | hematopoiesis

Numerous discoveries in medicine are results of experiments on different animal species. The most frequently used animals in hematopoiesis investigations are laboratory mice and rats, but so-called big animals, such as pigs, sheep, cats, dogs, and monkeys, evolution-wise closer to humans have a place in experimental hematology as well. The specific problematics of a certain animal specie can lead to fundamental knowledge on certain aspects of the process of hematopoiesis end the biology of stem cells in hematopoiesis. Furthermore, comparative investigations of certain phenomena in different species help in the recognition of the general rules in the living world. In the area f preclinicalinvesti- gations, animal models are an inevitable step in studies of transplantation biology of stem cells in hematopoiesis, as well as in studies of biologically active molecules which have an effect on the hematopoietic system. Knowledge acquired on animal models is applied in both human and veterinary medicine.
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