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Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)

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Author(s): Dekoninck J | Geurs F | De Loecker R | Deprest Y

Journal: Pragmatic and Observational Research
ISSN 1179-7266

Volume: 2011;
Issue: default;
Start page: 13;
Date: 2011;
Original page

ABSTRACT
J Dekoninck1, F Geurs1, R De Loecker2, Y Deprest21Department of Medical Oncology, 2Laboratory, Regional Hospital Sint Maria, Halle, BelgiumAbstract: In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.Keywords: bone resorption, bisphosphonates, CTX levels, VAS scoreĀ 
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