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Sildenafil Determination in Various Matrices: A Review

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Author(s): Massoud Mahmoudian

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 4;
Issue: 2;
Start page: 72;
Date: 2005;
Original page

Keywords: Sildenafil | HPLC | Pharmaceutical Preparations | Soft Drinks | Biological Liquids

ABSTRACT
Determination of sildenafil by various methods and in various media is reviewed in this paper. The methods used consist of ultraviolet (UV) spectroscopy, thin layer chromatography (TLC), and high-performance liquid chromatography (HPLC). These methods were used to determine the amount of sildenafil in pharmaceutical preparations, soft drinks, and biological liquids. HPLC was used for evaluation of pharmacokinetic parameters of sildenafil. It is concluded that HPLC is the most reliable and applicable method in this regard.
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