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SIMULTANEOUS ESTIMATION OF NEBIVOLOL HYDROCHLORIDE AND AMLODIPINE BESYLATE IN COMBINED TABLET DOSAGE FORM BY Q-ANALYSIS METHOD

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Author(s): Chandan Kumar Giri

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 5;
Start page: 13;
Date: 2010;
Original page

Keywords: Nebivolol hydrochloride | Amlodipine besylate | Spectrophotometric analysis | Q-Analysis method

ABSTRACT
A simple, accurate, precise, rapid and economicalspectrophotometric for simultaneous estimation of Nebivolol hydrochloride and Amlodipine besylate in combined tablet dosage form has been developed utilizing Q-analysis method or Absorbance ratio method. In this , absorbance is measured at two wavelengths, one being the iso-absorptive point 268nm (ƒÉ1) and the other being ƒÉmax of one of the sample components 282nm (ƒÉ2). Both the drugs obey Beerfs law in the concentration ranges employed for this . Result of the was validated statistically as well as by recovery studies.for simultaneous estimation of NH and AB in combined sample solutions was found to be simple, accurate and reproducible. Once the equations are determined, analysis required only the measurement of the absorbances of the sample solution at the two wavelengths selected, followed by a few simple calculations. It is a novel that can be employed for routine analysis in quality control or R & D laboratory.
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