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Simultaneous Estimation and Validation of Pseudoephidrine Sulphate and Desloratidine from Bulk and Tablets as hydrotropic solubilizing agent

Author(s): Smita Sharma, | Mukesh C. Sharma

Journal: Journal of Current Pharmaceutical Research
ISSN 0976-3171

Volume: 1;
Issue: 1;
Start page: 26;
Date: 2010;
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Keywords: Pseudoephidrine Sulphate | Desloratidine | Hydrotropic solubilization | urea.

Objective: Hydrotropic solubilisation technique is one of them. In the present investigation hydrotropic solution of 8M urea has been employed as solubilizing agent to solubilization poorly water soluble drug Pseudoephidrine Sulphate, Desloratidine, from fine powder of its tablet dosage form for spectrophotometric determination in ultraviolet region.Materials & Methods: Pseudoephidrine Sulphate, Desloratidine shows maximum absorbance at resulting solutions were measured at 274.4 nm and 289.1nm. Results of analysis were validated statistically and by recovery studies. The proposed method is new, simple, environment friendly, accurate and cost-effective and can be successfully employed in routine analysis of Pseudoephidrine Sulphate, Desloratidine in tablets.Results: The present paper describes application of hydrotropic solubilization phenomenon for the simultaneous estimation of Pseudoephidrine sulphate and Desloratidine in tablet dosage form by simultaneous equation method, and Multicomponent method. All two drugs showed good regression values at their respective wavelengths.Conclusion: The results of recovery study revealed that any small change in the drug concentration in the solution could be accurately determined by the proposed methods and low values of LOD and LOQ indicated good sensitivity of proposed methods.
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