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SIMULTANEOUS ESTIMATION AND VALIDATION OF PARACETAMOL AND DOMPERIDONE IN BULK AND TABLET DOSAGE FORM BY USING DIFFERENT SPECTOPHOTOETRIC METHOD

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Author(s): Hapse Sandip Appasaheb | Damale Pallavi Shankar | Dhumal Virashri Atmaram | Kapare Parmeshwar Subhash

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 9;
Start page: 180;
Date: 2013;
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Keywords: Paracetamol | Domperidone | Ultraviolet spectroscopy | Simultaneous equation Method | Dual Wavelength Method | Area under Curve Method.

ABSTRACT
Three simple, accurate and precise spectrophotometric methods have been developed for simultaneous determination of Paracetamol and Domperidone in a binary mixture. In Method I absorbance were measured at 258 nm and 292 nm corresponding to the absorbance maxima of Paracetamol and Domperidone. Concentration of each drug was obtained by using the absorptive values calculated for both drugs at wavelengths 258 nm, and 292 nm. Method II by Dual wavelength method, Paracetamol and Domperidone were quantified using principle that absorbance difference between two points on mixture spectra was directly proportional to concentration of component of interest and independent of interfering component. Method III describes Area under Curve and involves measurement of area under curve in the range of 288-296 nm (For PARA) and 247-269 nm (For DOM) for the analysis in methanol. Linearity range was observed in the concentration range of 5‐30 μg/ml for Paracetamol and Domperidone. Developed methods were applied to marketed formulation. The methods were validated statistically and recovery study was performed to confirm the accuracy of both methods.
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