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Simultaneous spectrophotometric estimation of Ciprofloxacin and Ornidazole in tablets

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Author(s): Patel S | Patel N | Patel M

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 68;
Issue: 5;
Start page: 665;
Date: 2006;
Original page

ABSTRACT
Two simple, sensitive, rapid, accurate and economical methods were developed for the estimation of ciprofloxacin and ornidazole in two-component solid dosage form. First method is based on the simultaneous equation, and second method is based on Q-analysis (absorbance ratio method). Ciprofloxacin has absorbance maxima at 271.4 nm, and ornidazole has absorbance maxima at 320 nm in distilled water. The linearity was obtained in the concentration range of 2-10 µg/ml for ciprofloxacin and 2-20 µg/ml for ornidazole. In the first method, the concentrations of the drugs were determined by using simultaneous equations; and in the second method, the concentrations of the drugs were determined by using ratio of absorbances at isoabsorptive point and at the λmax of one of the drugs. The results of analysis have been validated statistically and by recovery studies.
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