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SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF THIOCOLCHICOSIDE AND DEXKETOPROFEN TROMETAMOL IN PHARMACEUTICAL DOSAGE FORM

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Author(s): JalpeshT Bharatbhai Trivedi

Journal: International Journal of Biomedical and Advance Research
ISSN 2229-3809

Volume: 3;
Issue: 3;
Start page: 179;
Date: 2012;
Original page

Keywords: NSAIDS | Thiocolchicoside | DexketoprofenTrometamol

ABSTRACT
The present manuscript describes simple, sensitive, rapid, accurate, precise and economic dual wavelength spectrophotometric method for simultaneous determination of Thiocolchicoside and Dexketoprofen trometemol in combined tablet dosage form. The utility of dual wavelength data processing program is its ability to calculate unknown concentration of components of interest in a mixture containing an interfering component. The method was based on property of additivity of absorbances. The two wavelengths on UV spectrum of Thiocolchicoside were found out where it showed same absorbance, which were 368 nm and 284.60 nm. At 368 nm Thiocolchicoside showed some absorbance whereas Dexketoprofen trometemol showed zero absorbance. Both the drugs gave absorbance at 284.60 nm. The method involved solving of an equation based on measurement of absorbances at two wavelengths 284.6 and 368 nm. The two drugs follow Beer-Lambert’s law over the concentration range of 2-24 µg/ml. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.
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