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Simultaneous spectroscopic estimation of ezetimibe and simvastatin in tablet dosage forms

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Author(s): Rajput S | Raj H

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 69;
Issue: 6;
Start page: 759;
Date: 2007;
Original page

Keywords: Ezetimibe | simvastatin | simultaneous estimation | zero crossing method | antihyperlipidemic agents

ABSTRACT
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of ezetimibe and simvastatin in tablets using first order derivative zero-crossing method. Ezetimibe showed zero crossing point at 245.4 nm while simvastatin showed zero crossing point at 265.2 nm. The dA/dl was measured at 265.2 nm for ezetimibe and 245.4nm for simvastatin and calibration curves were plotted as dA/dl versus concentration, respectively. The method was found to be linear (r 2 >0.9994) in the range of 5-40 µg/ml for ezetimibe at 265.20 nm. The linear correlation was obtained (r 2 >0.9935) in the range of 5-80 µg/ml for simvastatin at 245.4 nm. The limit of determination was 0.39 and 0.12 µg/ml for ezetimibe and simvastatin, respectively. The limit of quantification was 1.10 and 0.4 µg/ml for ezetimibe and simvastatin, respectively. The method was successfully applied for simultaneous determination of ezetimibe and simvastatin in binary mixture.
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