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Skeletal muscle involvement in human immunodeficiency virus infection: A report of four cases

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Author(s): Sangle Shashikala | Dasgupta Abhijit | Ratnalikar Shripad | Kulkarni Rahul

Journal: Neurology India
ISSN 0028-3886

Volume: 58;
Issue: 6;
Start page: 939;
Date: 2010;
Original page

Keywords: Atrophy | HIV | HIV wasting syndrome | inflammation | muscle biopsy | polymyositis

ABSTRACT
Human immunodeficiency virus (HIV) may affect any part of the neuraxis and may affect skeletal muscle in many ways, ranging from myofiber atrophy in the wasting syndrome to inflammatory muscle disease and a host of opportunistic infections involving muscle. We report here a case series of 4 zidovudine-naοve patients with proven HIV infection with myopathy. One was a case of HIV wasting syndrome, and the three others were diagnosed as HIV polymyositis. Muscle biopsy proved invaluable in the characterization of these cases
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