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The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

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Author(s): Guilherme D. Brand | Raimunda C. Santos | Luisa Mayumi Arake | Valdelânia G. Silva | Leiz M. C. Veras | Vladimir Costa | Carlos Henrique N. Costa | Selma S. Kuckelhaus | José Guilherme Alexandre | Maria J. Feio | José Roberto S. A. Leite

Journal: Molecules
ISSN 1420-3049

Volume: 18;
Issue: 6;
Start page: 7058;
Date: 2013;
Original page

Keywords: antimicrobial peptides | dermaseptins | phylloseptins | Phyllomedusa | Leishmania

ABSTRACT
Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action.
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Tango Jona
Tangokurs Rapperswil-Jona