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Solid Dispersion of Nabumetone in Ethyl Cellulose - An Approach to Enhance the Solubility and Dissolution Rate

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Author(s): Prasobh GR* | Mohammed Sabir A.S | Sameera F. A | Jyothi B Nair | Soumya R.V.

Journal: Hygeia : Journal for Drugs and Medicines
ISSN 0975-6221

Volume: 1;
Issue: 1;
Start page: 33;
Date: 2009;
Original page

Keywords: Solid Dispersion | Ethyl cellulose | Nabumetone

ABSTRACT
The solubility characteristics of drugs remain the most challenging aspect in the formulation development. With the advent of combinatorial chemistry and high throughput screening the number of poorly soluble compounds has dramatically increased. The dissolution rate of drug from its dosage form is considered as an important parameter in the absorption. Dissolution is the rate-limiting step in the absorption of drugs from 1 solid dosage form especially when the drug is poorly water soluble. Poor wettability of drugs leads to the decrease in their bioavailability. Increasing the surface area of the drug particle may curb out this problem. For drugs whose GI absorption is rate limited by dissolution, reduction of particle size increases the rate of absorption and total bioavailability. This is common with drugs of poor water solubility. Solid dispersion of Nabumetone is already carried with methyl cellulose. The main perspective of this study aims at overcoming these problems by solid dispersion technology using carriers like ethyl cellulose as well as other natural, semi synthetic and synthetic carriers with a view to develop fast release formulation of Nabumetone improving its dissolution characteristics. Nabumetone is an effective NSAID, it is practically insoluble in water, where the dissolution is rate limiting. The dissolution of Nabumetone from the tablet formulation containing the solid dispersion was found to be fast and rapid when compared with marketed formulation
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