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Solid Lipid Nanoparticles (SLN’S) – Trends and Implications in Drug Targeting

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Author(s): Vivek Ranjan Sinha | Saurabh Srivastava | Honey Goel | Vinay Jindal

Journal: International Journal of Advances in Pharmaceutical Sciences
ISSN 0976-1055

Volume: 1;
Issue: 3;
Date: 2011;
Original page

Keywords: Colloidal Drug Carriers | Nanoparticles | Drug Targeting | Biodistribution

ABSTRACT
The era of nanotechnology has revolutionized the drug delivery system and persuades new research strategies to flourish. Solid lipid nanoparticles (SLN) has attracted various research groups and companies since the early 1990s, however research in the SLNs is still in its infancy. ‘SLN technology based therapy’ made available a novel and sound platform for therapeutics. Solid lipid nanoparticles have been developed as an important strategy to deliver drugs. These lipid nanoparticles modify drug release, body distribution and kinetics of associated drugs. Other applications of SLNs are tissue/cell targeting of drugs and reduction of unwanted side effects by controlled release. This paper reviews the production techniques, ingredients employed and various applications, also having consideration on various aspects and benefits of solid lipid nanoparticles as colloidal drug carriers.Keywords: Colloidal Drug Carriers, Nanoparticles, Drug Targeting, Biodistribution
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