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Solubility and Dissolution Improvement of Aceclofenac using Different Nanocarriers

Author(s): Faiyaz Shakeel | Wafa Ramadan | Sheikh Shafiq

Journal: Journal of Bioequivalence & Bioavailability
ISSN 0975-0851

Volume: 01;
Issue: 02;
Start page: 039;
Date: 2009;
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Keywords: Aceclofenac | Nanoemulsions | Lipid nanosuspensions | Polymeric nanosuspensions | Solubility | Dissolution

The aim of the present investigation was to improve solubility and dissolution of the lipophilic drug aceclofenac using three nanocarriers namely nanoemulsion, solid lipid nanosuspension and polymeric nanosuspension. The solubility of aceclofenac in distilled water and different nanocarriers was determined using the UV spectrophotometer method at the wavelength of 274 nm. Dissolution studies of pure aceclofenac suspension and its nanocarriers were performed using USP dissolution apparatus in distilled water. The highest solubility (198.53 mg/ml) as well as % dissolution (99.5) of aceclofenac was obtained with nanoemulsion formulation as comparedto lipid and polymeric nanosuspension. The results of solubility and dissolution were highly significant in nanoemulsion as compared to lipid and polymeric nanosuspension (P
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