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Some considerations about the development of technique for the in vivo comet assay in leukocytes of peripheral blood and liver cells

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Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 26;
Start page: 1;
Date: 2010;
Original page

Keywords: in vivo comet assay | technique | leukocytes of peripheral blood | liver cells

ABSTRACT
In 1988, Singh and collaborators developed the alkaline variant of the individual cells electrophoresis (comet assay), providing for the first time the data at level of individual cell. This article had as objective to provide of the researchers that they work carrying out the genotoxic evaluations some considerations about the experimental technique of the comet assay starting from leukocytes of peripheral blood and liver cells. We kept in mind for each procedure the solutions to prepare, experimental procedure and evaluation.
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