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Some considerations on the acute toxicity determination

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Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Yulieé López Feria | Mildrey Fariñas Medina | Juan Francisco Infante Bourzac | Daiyana Díaz Rivero | Jorge Luis Prieto Díaz

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 22;
Start page: 1;
Date: 2009;
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Keywords: Acute toxicity | alternative methods | 3 “R” principles | unique exhibition

ABSTRACT
The acute toxicity refers to the quick development of symptoms and effects after the application of a relatively high unique dose or it commonly is related with the immediate damages generated by sufficiently big unique dose. The animals observation is carried out after the administration of the substance and it lasts up to 14 days, after which the animals are sacrificed and anatomopatological analyzed. To fulfill 3 " R " principles they have been approved the three reduction methods and refinement of the acute toxicity: the fixed dose, the acute toxic class and the up/down method. Keeping in mind these antecedents, we trace ourselves as objective of this work to give some current considerations on the determination of the acute toxicity of a substance, according to the principle before mentioned. For that which we include the types of data, types of damages caused by the toxic materials, objectives of the acute toxicity, their importance, classification of the acute evaluations, general toxic effects, median lethal dose determination (DL50), 3 “R” principles (Replacement, Reduction and Refinement), classic and alternative methods and lastly like the acute toxicity of a substance should be measured
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