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Some considerations on the animal models use in the teratogenesis assays

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Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Yulieé López Feria | Juan Francisco Infante Bourzac | Mildrey Fariñas Medina | Daiyana Díaz Rivero

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 21;
Start page: 22;
Date: 2009;
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Keywords: Teratogenesis | rats | rabbits | animal models | reproduction toxicology

ABSTRACT
Teratology is the scientific discipline that, inside the veterinary and the medicine, its studies the unsightly creatures, those natural creations in a species that don't respond to the common pattern. At the present time standardized experimental protocols are used that they are considered acceptable and solid evaluations of the embrio-fetal development. With them it is possible to evaluate the effect of a substance given on practically all the reproductive process phases. However, the great number of chemical substances that should be evaluated with these methods has taken to the development of in vitro systems that could be used to establish priorities in the animals tests, but these systems have not been able to even this way to replace the tests in animals, being even necessary these in vivo assays, which manifest with more truthfulness the teratogenic effect or not of x product to evaluate. For that the objective of this small work is to give a current panoramic about some considerations to keep in mind in the teratogenesis assays in rodents and non rodent species it is the case of the rabbit, as this established one according to the Organisation for Economic Co-operation and Development (OECD) and International Conference on Harmonization (ICH) regulations, will be useful for experimental toxicology researchers, in the toxicology reproduction branch. We kept in mind the experimental design that should be complete when using rats or rabbits, as well as the variables that should be measured and analyzed.
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