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Some considerations on the inmunotoxicology studies for a novel vaccine adjuvant

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Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Yulieé López Feria | Daiyana Díaz Rivero

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 25;
Start page: 9;
Date: 2009;
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Keywords: Inmunotoxicology | assays | novel vaccine adjuvant

ABSTRACT
In our days its stands out the adjuvants use in most of the vaccine candidates, as enhancers of the immune response, but in general the adjuvants existen, presents adverse and undesirable effects, mainly of toxic nature, results that they have been good to affirm for several experts and studious of this matter that for them the ideal adjuvant doesn't exist. This revision has as objective to give some considerations on the inmunotoxicology studies required in a novel vaccine adjuvant. We kept in mind the values that determine general toxicity in the immune system. Studies that can be included in a general way in the registration of the novel vaccine adjuvant, general components and specific components which includes hematology and clinical chemistry, anatomopatologic analysis of all the organs and the lymphoid organs weight , histopatoligic exam, T dependent antibodies response, immunophenotyping, as well as the cellular activity of the natural killer (NK) cells activity assays, macrophage/neutrophil function and lastly the assays to measure cells-mediated immunity. They are numerous the evaluations to carry out to be able to register and to validate a novel adjuvant, where the inmunotoxicologic component has a great importance, which allow determining the toxic effect at all the possible levels, this to our approach has been to diminish the risk to undesirable effects of the vaccines used in human and animals.
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