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SOS assay, a current review.

Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Juan Francisco Infante Bourzac | Dayisell Lazara Curveco Sánchez

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 21;
Start page: 1;
Date: 2009;
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Keywords: SOS assay | lexA | recA | radioprotector | genetic toxicology

In prokarionts it is denominated SOS response, to the system cellular emergency that allows the bacterial survival before the detention of the DNA replicación that has been damaged by genotoxic agents. The SOS response consists on the induction of more than 20 genes that are low the control of the recA/lexA circuit. The recA protein, is the positive regulator of the circuit, it is activated after the interaction with the sign molecule: DNA of simple chain, lexA is the negative regulator, well-known as the transcriptional represor of all the SOS genes in those that the own lexA and recA are included. The present work had as objective to current on the SOS phenomenon topic and SOS response, highlighting their utility like genotoxic assay commonly call (SOS assay), being useful to the researchers that work the genetic toxicology in vitro topic, to determine the genotoxicity and radioprotective of their products. We made allusion the ionizing radiation effect on the DNA, bacterial SOS response, repair for recombination, SOS mutagenesis, other genes involved in the SOS response, bacterial assay based on transcriptionals melt of SOS genes and lastly the antimutagenesis and radioprotective linked to this assay.
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