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Spasmolytic Activity of Piper Nigrum Fruit Aqueous Extract on Rat Non-Pregnant Uterus

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Author(s): Mohammad Kazem Gharib Naseri | Hoda Yahyavi

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 6;
Issue: 1;
Start page: 35;
Date: 2007;
Original page

Keywords: Piper nigrum fruit | Rat | Uterus | Spasmolytic

ABSTRACT
Black pepper (Piper nigrum) from Piperaceae and its main ingredient (piperine) reduces gastric emptying in rats. In Iranian traditional medicine, black pepper is used to relief the menorrhalgia in women. The aim of this study was to investigate the effect of black pepper fruit aqueous extract on non-pregnant rat uterus contractions and the mechanism(s) of its action. To prepare the extract, black pepper powder was added to boiling distilled water and then, solvent was evaporated. Uterus was dissected from non-pregnant adult rat (Wistar) and in De Jalon solution the tissue contractions were recorded isometrically under 1 g tension. The extract (0.125-2 mg/ml) reduced the uterus contractions induced by KCl (60 mM) and oxytocin (10 mU/ml) dose dependently (P
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