Academic Journals Database
Disseminating quality controlled scientific knowledge

THE SPECTROFLUORIMETRY METHOD FOR DETERMINATION OF NALIDIXIC ACID IN HUMAN PLASMA

ADD TO MY LIST
 
Author(s): A Moghbel | B Makhmalzadeh

Journal: Jundishapur Journal of Natural Pharmaceutical Products
ISSN 1735-7780

Volume: 1;
Issue: 1;
Start page: 41;
Date: 2006;
Original page

Keywords: Spectrofluorimetry | Fluorescent Drug | Nalidixic Acid | Formulation | Bioavailability

ABSTRACT
This paper describes a precise and sensitive method for analysis of Nalidixic Acid (NA) in plasma following the oral administration of a therapeutic dose in humans. Most procedures used for quantitation of NA are based on its fluorescence. The spectrofluorimetry is the best choice for a fluorescent drug, regarding its specificity and sensitivity of the method. Also, it is recommended for the fluorescent drug assay in pharmaceutical companies as a cheaper, more routin and time saving right way in comparison with chromatographic methods. For the practical determination, a new formulation of nalidixic acid tablet was used as a modle and compared with a work standard by invitro and invivo evalutions as a crossover study in 12 normal volunteers. The friability, weight variation, assay and dissolution test for both products were almost the same and approved by USP requirements.The plasma samples and pharmacokinetic parameters were determined. Results of the tests and their statistical analysis indicated no significant differences (P
Why do you need a reservation system?      Save time & money - Smart Internet Solutions