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Spectrophotometric estimation of ketotifen fumarate from tablet formulations

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Author(s): Singhvi I | Sachdeva D

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 71;
Issue: 1;
Start page: 66;
Date: 2009;
Original page

Keywords: Spectrophotometric | ketotifen fumarate | 2-nitroso- napthol-4-sulphonic acid and rhodizonic acid

ABSTRACT
Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of ketotifen fumarate from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of with 2-nitroso- napthol-4- sulphonic acid and rhodizonic acid. The extracted complex of drug with 2-nitroso- napthol-4- sulphonic acid (method-I), showed absorbance maxima at 436.5 nm and with rhodizonic acid (method-II), showed absorbance maxima at 489.5 nm. The linearity range for both the developed methods was observed in the concentration range of 50-250 µg/ml of drug. Results of analysis for both the developed methods were validated statistically and by recovery studies.
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