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SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF CHLORZOXAZONE AND DICLOFENAC SODIUM IN SYNTHETIC MIXTURE

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Author(s): Patel Satish A | Prajapati Kalpesh M

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 293;
Date: 2012;
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Keywords: Diclofenac sodium | Chlorzoxazone | Recovery | Synthetic mixture | Simultaneous equations | Validation.

ABSTRACT
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of diclofenac sodium and chlorzoxazone in bulk and synthetic mixture. The method is based on the simultaneous equations for analysis of both the drugs using 0.1 N NaOH as solvent. Diclofenac sodium has absorbance maxima at 276 nm and chlorzoxazone has absorbance maxima at 288 nm in 0.1 N NaOH. The linearity was obtained in the concentration range of 2-24 μg/ml and 2-24 μg/ml for diclofenac sodium and chlorzoxazone, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 100.4 ± 1.3 and 100.2 ± 0.56 for diclofenac sodium and chlorzoxazone, respectively. The method was successfully applied to laboratory prepared synthetic mixture because no interference from the mixture excipients was found. The suitability of this method for the quantitative determination of diclofenac sodium and chlorzoxazone was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of diclofenac sodium and chlorzoxazone in combination. The results of analysis have been validated statistically and by recovery studies.
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