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SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF EPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN SYNTHETIC MIXTURE

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Author(s): Patel Paresh U | Patel Sejal K | Patel Umang J

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 203;
Date: 2012;
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Keywords: Diclofenac sodium | Eperisone hydrochloride | Recovery | Simultaneous equations method | Validation.

ABSTRACT
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of diclofenac sodium and Eperisone hydrochloride in bulk and synthetic mixture. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Diclofenac sodium has absorbance maxima at 281 nm and Eperisone hydrochloride has absorbance maxima at 255 nm in methanol. The linearity was obtained in the concentration range of 2-20 μg/ml and 2-20 μg/ml for diclofenac sodium and Eperisone hydrochloride, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 100.03 ± 0.16 and 99.81 ± 0.82 for diclofenac sodium and Eperisone hydrochloride, respectively. The method was successfully applied to laboratory prepared synthetic mixture because no interference from the mixture excipients was found. The suitability of this method for the quantitative determination of diclofenac sodium and Eperisone hydrochloride was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of diclofenac sodium and Eperisone hydrochloride in combination. The results of analysis have been validated statistically and by recovery studies.
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