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SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TRETINOIN AND CURCUMIN COMBINATION IN PURE FORM

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Author(s): Mallik Santanu | Kshirsagar M. D. | Saini Vipin

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 151;
Date: 2011;
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Keywords: Spectrophotometry | Curcumin | Herbal drug | Tretinoin

ABSTRACT
The present study is very optimistic towards the development in dosage forms loaded with synthetic and herbal drug combination. The simultaneous estimation was done by using spectrophotometric method, using ethanol as solvent. Stock solutions of Tretinoin and Curcumin were diluted to final concentration of 5µg/ml. UV scan of 5µg/ml solution of both drugs combination showed the absorption maxima at 349.2 nm and 427.2 nm. respectively by using ethanol as blank. Simultaneous estimation method also indicates the interference between both the drugs at their respective λ max of one another. By replacing A1, A2, E1a, E1b, E2a and E2b values in simultaneous equation, C1 and C2 were calculated and found 4.94 µg/ml and 5.0 µg/ml respectively. The method developed was found suitable as percentage recovery was 99% and 100% for Curcumin and Tretinoin respectively indicating no interference between both the drugs.
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