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Spectrophotometric Methods for the Determination of Allylestrenol in Pure and Pharmaceutical Dosage Forms

Author(s): Syeda Kulsum1, M.Padmalatha1*, A.Sravani1, T.Snehalatha1, G.Vidyasagar2.

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3226;
Date: 2011;
Original page

Keywords: Spectrophotometer | Pharmaceutical dosage forms | allylestrenol | 1 | 2-napthoquinoe sulphonic acid sodium salt | bromocresol green and crystal violet.

Three visible spectrophotometric methods have been developed for the determination of allylestrenol either in pure form or in their pharmaceutical formulations.The developed methods are based on reaction of allylestrenol with 1,2-napthoquinoe sulphonic acid sodium salt, bromocresol green and crystal violet. They arequantified spectrophotometrically at their absorption maximum at 346 nm (Method A), 421nm (Method B) and 585 nm (Method C). Beer’s law was obeyed in theconcentration ranges of 60-80 μg/ml, 30-50 μg/ml and 50-80 μg/ml for the three methods respectively. The colors were found to be stable for more than 4 hours.The proposed methods were successfully applied for determination of the allylestrenol in their pharmaceutical formulations and the results compared favorablyto that of reference methods, hence are recommended for quality control and routine analysis.
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