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Spectrophotometric methods for the determination of mesalamine in bulk and pharmaceutical dosage forms

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Author(s): Sasmita Kumari Acharjya | Alok Sahu | Srikanta Das | Padhy Sagar | M. Mathrusri Annapurna

Journal: Journal of Pharmaceutical Education and Research
ISSN 0976-8173

Volume: 1;
Issue: 1;
Start page: 63;
Date: 2010;
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Keywords: Mesalamine | derivative spectroscopy | Area under curve | UV spectrometry

ABSTRACT
Five simple, precise and cost effective spectrophotometric methods have been developed for the estimation of mesalamine in bulk and its pharmaceutical formulations. Mesalamine shows λmax at 232.0 nm in zero order derivative spectrum (Method A), 241.0 nm in first order derivative spectrum (Method B), 244.5 nm in second order derivative spectrum (Method C) and 240.5 nm in third order derivative spectrum (Method D). Method E is based on calculation of Area under Curve (AUC) for analysis of mesalamine in the wavelength range of 227.0– 237.0 nm. The drug follows the Beer-Lambert’s law in the concentration range of 2.0 – 25.0 μg/ml in all the methods. The methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization. All validation parameters were within the acceptable range. The developed methods were successfully applied to estimate the amount of mesalamine in bulk and pharmaceutical dosage forms.

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