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The spectrum of ?-thalassemia mutations in the Arab populations

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Author(s): Zahed Laila

Journal: Journal of Biomedicine and Biotechnology
ISSN 1110-7243

Volume: 1;
Issue: 3;
Start page: 129;
Date: 2001;
Original page

ABSTRACT
The Arab countries encompass a wide region stretching from the Persian Gulf to the Atlantic Ocean. The Arab population is quite heterogeneous and has experienced various invasions and migrations throughout history. ?-thalassemia is endemic in all countries of the Arab world. Our review of the molecular basis of ?-thalassemia in various Arab countries reveals the presence of 52 mutations, which are mostly of Mediterranean and Asian origin. The distribution of mutations re?ects the geographical and historical backgrounds of each region. However, no speci?c mutation is con?ned to the Arabs, although some Arab countries do have unique mutations.
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