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Spontaneous and induced frequency of anomalies in the head sperm morphology in NMRI mice

Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Dayisell Lazara Curveco Sánchez

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 20;
Start page: 2;
Date: 2009;
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Keywords: Spontaneous | induced | head sperms morphology | NMRI mice | cyclophosphamide

The spermogenesis, is efficient and important process for the species continuous, one of its characteristics is that apparent great resistance to the damage. In the reproductive system of mice have been described on spermogenesis effects, process of highly specialized diferenciation that includes a series of transcriptionals and morphology changes. Among the systems that are used to evaluate the damages happened in the germinal cells is the assays based on the Wyrobek and Bruce morphology approaches and the OMS, that which allows the study and classification of the head sperms morphology when including inside the classifications, normal, abnormal heads and inside this last banana form morphology, amorphous, without hook and two tail, given their great sensibility this tool allows to evaluate the spermatic concentration changes, as well as the increase of the heads spontaneous frequency of sperms morphology abnormal, to detect the irreversible damage that is fixed by a relatively long time period. In this article we reported the sperms concentration and basal frequency of appearance of anomalies in the head sperms in NMRI mice, as well as the events induced frequency after the cyclophosphamide administration by intraperitoneal route (50 mg/kg), mutagen reference used as positive control. We could conclude that the NMRI mice, constitutes a good model to use in the genotoxicology studies, given the drop spontaneous frequency of important genotoxic indicative like they are those included in this work, and the sensibility of the cyclophosphamide action.
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