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STAT3, HIF-1alpha, EPO and EPOR - signaling proteins in human primary ductal breast cancers.

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Author(s): Andrzej Wincewicz | Mariola Sulkowska | Mariusz Koda | Tomasz Leśniewicz | Luiza Kanczuga-Koda | Stanisław Sulkowski

Journal: Folia Histochemica et Cytobiologica
ISSN 0239-8508

Volume: 45;
Issue: 2;
Start page: 81;
Date: 2007;
Original page

ABSTRACT
STAT3 upregulates expression of HIF-1 induced EPO. Receptor EPOR was reported to activate STAT3. Our study was aimed at demonstration of tissue immunoreactivities of those proteins and determination of their relationships in reference to clinicopathological variables of breast cancers. We detected STAT3, HIF-1alpha, EPO and EPOR in specimens of 76 human, female, ductal breast cancers by immunohistochemistry. STAT3 was detected in 38 of 76 cancers (50%). HIF-1alpha was found in 55 cases (72%). EPO positive tumors comprised 89% of all the cancers (68 cases). EPOR was also visualized in 55 cases (72%). Anti-HIF-1alpha and anti-STAT3 stained nuclei and cytoplasm of breast cancer cells in diffuse and finely granular fashion. Strong membranous expressions of EPO and EPOR were distributed in cytoplasmic and membranous granularity or diffuse staining. STAT3 correlated with HIF-1 in general (r=0.4012, p
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